My research interests lie within the realm of deciphering complex biological systems. Elucidating the mechanisms driving multifactorial phenotypes is especially enigmatic, as they often arise from the dynamic interplay between intrinsic genetic regulation and extrinsic environmental cues. I am particularly interested in how bacteria detect and respond to host-derived metabolic stress signals to rewire regulatory and metabolic networks that control survival, adaptation, and virulence.

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A central focus of my work is urate, a purine degradation product produced by the host. In Burkholderia thailandensis, urate binds to the global regulator MftR, inducing conformational changes that alter its DNA-binding activity and trigger genome-wide transcriptional shifts. I use ChIP-seq to map MftR targets and build regulatory networks, alongside quantitative proteomics and untargeted metabolomics to track changes in protein expression and metabolism under stress. I also investigate efflux pumps, key bacterial systems for resisting environmental and host-derived stress. In addition, I study purine riboswitches, structured non-coding RNAs that sense metabolites, and I develop AI-driven models to identify and classify these regulators across bacterial genomes. My long-term goal is to target global regulators like MftR to disrupt bacterial sensing of host-derived signals such as urate, providing a novel route to disarm virulence and combat antibiotic resistance.